By Prof. Dr. U. Trendelenburg (auth.), Prof. Dr. Peter Riederer, Prof. Dr. Moussa B. H. Youdim (eds.)
Read or Download Amine Oxidases and Their Impact on Neurobiology: Proceedings of the 4th International Amine Oxidases Workshop, Wurzburg, Federal Republic of Germany, July 7–10, 1990 PDF
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Additional info for Amine Oxidases and Their Impact on Neurobiology: Proceedings of the 4th International Amine Oxidases Workshop, Wurzburg, Federal Republic of Germany, July 7–10, 1990
Besides these intraserotonergic interactions, influences on other transmitter systems are described, too (see review Meltzer and Lovy, 1987). Some antidepressants act by removing the inhibitory effect of serotonergic on catecholaminergic neurones (Eccleston, 1981). The 5-HT1A agonist ipsapirone and 8-0H-DPAT increase NE turnover, probably leading to a p-down regulation. There seems to be interaction with the dopaminergic system. An increase of cerebrospinal fluid homovanillic acid (CSF HV A) is described after serotonergic antidepressants.
It is the purpose of this communication to describe the current status of progress in using PET to image, in intact animals and in humans, the integrity and function of dopaminergic neurons in brain and noradrenergic neurons in the peripheral sympathetic nervous system. Imaging striatal dopaminergic neurons Because catecholamines do not penetrate the blood-brain barrier, replacement of dopamine which is deficient in brain of patients with Parkinson's disease requires use of L-DOPA, the amino acid precursor of this neurotransmitter.
LsF-6-FDA was synthesized more rapidly than was 14C-dopamine and reached a peak concentration at about 20 minutes after its administration. At that time, 6FDA accounted for the major fraction of the lsF in the striatum and 6FDOPAC was the major metabolite. After about 90 min, lsF-HVA levels exceeded those of 6F-DA and of 6F-DOPAC. In areas of brain, such as the occipital cortex, in which there is little endogenous dopamine, the major IsF-containing substance was 3-0-methyl-6F-DOPA. , 1988). The presence of these lsF_ labelled compounds precludes precise measurement of the rate of decline in concentration of lsF -dopamine.
Amine Oxidases and Their Impact on Neurobiology: Proceedings of the 4th International Amine Oxidases Workshop, Wurzburg, Federal Republic of Germany, July 7–10, 1990 by Prof. Dr. U. Trendelenburg (auth.), Prof. Dr. Peter Riederer, Prof. Dr. Moussa B. H. Youdim (eds.)