By Howard Rogers and Roy G. Spector (Auth.)
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Extra info for An Introduction to Mechanisms in Pharmacology and Therapeutics
Conversely the alkaloid veratrine, which keeps the sodium channel open, produces prolonged depolarisation in myocardial and other cells. (b) Drugs and the physical properties of membranes The potency of anaesthetics increases with their fat solubility. In fact it has been observed that with a large number of such drugs, unconsciousness occurs when the concentration of the substance has attained a certain value in the cell lipids. With this type of pharmacological action, the chemical nature of the general anaesthetic agent is unimportant except in so far as it affects lipid solubility (Chapter 7).
There is evidence that depolarisation and smooth muscle contraction are not necessarily linked. Depolarisation of uterine muscle with high concentrations of potassium, cannot abolish its responsiveness to acetylcholine.
Mackay D. ( 1966) The mathematics of drug-receptor interactions /. Pharm. Pharmac, 18, 201 - 222. , Molinoff P. and Potter T. L. (1971) Isolation of cholinergic receptor protein of Torpedo electric tissue Nature 2 2 9 , 5 5 4 - 557. Molecular Properties of Drug Receptors - Ciba Foundation Symposium (1970) Eds. R. Porter and M. O'Connor, J. and A. Churchill. , Wyman J. and Changeux J - P (1965) On the nature of allosteric transitions: a plausible model J. Mol. Biol. 12, 88 - 118. O'Brien R. , Eldefrawi M.
An Introduction to Mechanisms in Pharmacology and Therapeutics by Howard Rogers and Roy G. Spector (Auth.)